diff --git a/.portsignore b/.portsignore
index c6c7c83020b2..16aa60bde9cc 100644
--- a/.portsignore
+++ b/.portsignore
@@ -80,6 +80,7 @@ archivers/squsq
 archivers/stuffit
 archivers/thunar-archive-plugin
 archivers/v1541commander
+archivers/vbz-compression
 archivers/xarchive
 archivers/xarchiver
 archivers/zipper
diff --git a/archivers/Makefile b/archivers/Makefile
index ee180ab9b0f9..7178b4b77ad2 100644
--- a/archivers/Makefile
+++ b/archivers/Makefile
@@ -243,7 +243,6 @@
     SUBDIR += upx
     SUBDIR += urbackup-client
     SUBDIR += urbackup-server
-    SUBDIR += vbz-compression
     SUBDIR += xdms
     SUBDIR += xmill
     SUBDIR += zchunk
diff --git a/archivers/vbz-compression/Makefile b/archivers/vbz-compression/Makefile
deleted file mode 100644
index 5c422d98f6d6..000000000000
--- a/archivers/vbz-compression/Makefile
+++ /dev/null
@@ -1,31 +0,0 @@
-PORTNAME=	vbz-compression
-DISTVERSION=	1.0.13
-CATEGORIES=	archivers
-
-MAINTAINER=	jwb@FreeBSD.org
-COMMENT=	Variable byte integer encoding to compress Oxford Nanopore signal data
-WWW=		https://github.com/nanoporetech/vbz_compression
-
-LICENSE=	MPL20
-LICENSE_FILE=	${WRKSRC}/LICENCE.txt
-
-BUILD_DEPENDS=	streamvbyte>=0.4.1:archivers/streamvbyte
-LIB_DEPENDS=	libhdf5.so:science/hdf5 \
-		libzstd.so:archivers/zstd
-
-USES=		cmake
-USE_GITHUB=	yes
-USE_LDCONFIG=	${PREFIX}/hdf5/lib/plugin
-
-GH_ACCOUNT=	nanoporetech
-GH_PROJECT=	vbz_compression
-
-CMAKE_ARGS=	-DENABLE_CONAN=OFF \
-		-DENABLE_PERF_TESTING=OFF \
-		-DENABLE_PYTHON=OFF \
-		-DSTREAMVBYTE_INSTALL_DIR=${LOCALBASE} \
-		-DSTREAMVBYTE_STATIC_LIB=${LOCALBASE}/lib/libstreamvbyte.a
-
-PLIST_FILES=	hdf5/lib/plugin/libvbz_hdf_plugin.so
-
-.include <bsd.port.mk>
diff --git a/archivers/vbz-compression/distinfo b/archivers/vbz-compression/distinfo
deleted file mode 100644
index 81bc0b2ac701..000000000000
--- a/archivers/vbz-compression/distinfo
+++ /dev/null
@@ -1,3 +0,0 @@
-TIMESTAMP = 1739627810
-SHA256 (nanoporetech-vbz_compression-1.0.13_GH0.tar.gz) = 36cb0581391a0b59f63bf9f7046181bea9a0901c59c3bba689d66f5d7d7f3748
-SIZE (nanoporetech-vbz_compression-1.0.13_GH0.tar.gz) = 5364717
diff --git a/archivers/vbz-compression/files/patch-CMakeLists.txt b/archivers/vbz-compression/files/patch-CMakeLists.txt
deleted file mode 100644
index c1d4296057ec..000000000000
--- a/archivers/vbz-compression/files/patch-CMakeLists.txt
+++ /dev/null
@@ -1,42 +0,0 @@
---- CMakeLists.txt.orig	2025-01-14 12:40:34 UTC
-+++ CMakeLists.txt
-@@ -151,39 +151,6 @@ find_package(Sanitizers)
- find_package(zstd 1.3.1 REQUIRED)
- find_package(Sanitizers)
- 
--get_filename_component(STREAMVBYTE_SOURCE_DIR
--    third_party/streamvbyte
--    ABSOLUTE
--)
--set(STREAMVBYTE_INSTALL_DIR "${CMAKE_BINARY_DIR}/streamvbyte_lib/")
--set(STREAMVBYTE_PREFIX ${CMAKE_BINARY_DIR}/streamvbyte)
--set(STREAMVBYTE_STATIC_LIB_NAME ${CMAKE_STATIC_LIBRARY_PREFIX}streamvbyte${CMAKE_STATIC_LIBRARY_SUFFIX})
--set(STREAMVBYTE_STATIC_LIB_SUBDIR ".")
--get_property(is_multi_config GLOBAL PROPERTY GENERATOR_IS_MULTI_CONFIG)
--if (is_multi_config)
--    set(STREAMVBYTE_STATIC_LIB_SUBDIR "$<CONFIG>")
--endif()
--ExternalProject_Add(
--    streamvbyte
--    SOURCE_DIR ${STREAMVBYTE_SOURCE_DIR}
--    UPDATE_DISCONNECTED TRUE
--    PREFIX ${STREAMVBYTE_PREFIX}
--    CMAKE_ARGS
--        -D CMAKE_INSTALL_PREFIX=${STREAMVBYTE_INSTALL_DIR}
--        -D CMAKE_OSX_DEPLOYMENT_TARGET=${CMAKE_OSX_DEPLOYMENT_TARGET}
--        -D CMAKE_OSX_ARCHITECTURES=${CMAKE_OSX_ARCHITECTURES}
--        -D STREAMVBYTE_SANITIZE=${SANITIZE_ADDRESS}
--        -D STREAMVBYTE_SANITIZE_UNDEFINED=${SANITIZE_UNDEFINED}
--    # We need to tell CMake about libraries we will link to, otherwise some generators (eg: Ninja)
--    # complain about how knowing how to build libstreamvbyte_static.a, for example.
--    # Ideally, we'd set a hypothetical INSTALL_BYPRODUCTS, and link to the installed file, but that
--    # doesn't seem to be an option.
--    BUILD_BYPRODUCTS "<BINARY_DIR>/${STREAMVBYTE_STATIC_LIB_SUBDIR}/${STREAMVBYTE_STATIC_LIB_NAME}"
--)
--ExternalProject_Get_Property(streamvbyte BINARY_DIR)
--set(STREAMVBYTE_STATIC_LIB "${BINARY_DIR}/${STREAMVBYTE_STATIC_LIB_SUBDIR}/${STREAMVBYTE_STATIC_LIB_NAME}")
--
--
- ########################################################################
- #
- # Warnings
diff --git a/archivers/vbz-compression/files/patch-vbz_CMakeLists.txt b/archivers/vbz-compression/files/patch-vbz_CMakeLists.txt
deleted file mode 100644
index 3af5ffc7773f..000000000000
--- a/archivers/vbz-compression/files/patch-vbz_CMakeLists.txt
+++ /dev/null
@@ -1,15 +0,0 @@
---- vbz/CMakeLists.txt.orig	2025-01-14 12:42:19 UTC
-+++ vbz/CMakeLists.txt
-@@ -24,12 +24,6 @@ target_include_directories(vbz
-         ${STREAMVBYTE_INSTALL_DIR}/include
- )
- 
--# This explicit dependency is required to make sure the header files are installed into the right
--# location before we try building against them.
--add_dependencies(vbz
--    streamvbyte
--)
--
- option(VBZ_DISABLE_SSE3 "Disable SSE3 optimisations" OFF)
- if ((WIN32 OR CMAKE_SYSTEM_PROCESSOR MATCHES "x86_64") AND NOT VBZ_DISABLE_SSE3)
-     message(STATUS "SSE3 optimisations enabled")
diff --git a/archivers/vbz-compression/pkg-descr b/archivers/vbz-compression/pkg-descr
deleted file mode 100644
index 5579d805964c..000000000000
--- a/archivers/vbz-compression/pkg-descr
+++ /dev/null
@@ -1,7 +0,0 @@
-VBZ Compression uses variable byte integer encoding to compress Oxford
-Nanopore signal data.
-The performance of VBZ is achieved by taking advantage of the properties of the
-raw signal and therefore is most effective when applied to the signal dataset.
-Other datasets you may have in your Fast5 files will not be able to take
-advantage of the default VBZ settings for compression. VBZ will be used as the
-default compression scheme in a future release of MinKNOW.