diff --git a/science/afni/Makefile b/science/afni/Makefile
index a7ebfe299472..d8564d4df02e 100644
--- a/science/afni/Makefile
+++ b/science/afni/Makefile
@@ -2,8 +2,7 @@
 
 PORTNAME=		afni
 DISTVERSIONPREFIX=	AFNI_
-DISTVERSION=		20.3.04
-PORTREVISION=		1
+DISTVERSION=		21.0.00
 CATEGORIES=		science biology graphics perl5 python
 
 MAINTAINER=	ports@FreeBSD.org
diff --git a/science/afni/distinfo b/science/afni/distinfo
index 55e10a492125..788099f5940d 100644
--- a/science/afni/distinfo
+++ b/science/afni/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1608908073
-SHA256 (afni-afni-AFNI_20.3.04_GH0.tar.gz) = eb31b026b2783323f3bd33e433654abc7d86327a2cb75c17bb9f801047ac7dd0
-SIZE (afni-afni-AFNI_20.3.04_GH0.tar.gz) = 43278432
+TIMESTAMP = 1610099214
+SHA256 (afni-afni-AFNI_21.0.00_GH0.tar.gz) = ec9f6c2e827aad1cb1f08a1b46eeca4a14b42f126140ea44f016f781086c43d5
+SIZE (afni-afni-AFNI_21.0.00_GH0.tar.gz) = 43261011
diff --git a/science/afni/pkg-plist b/science/afni/pkg-plist
index e870504152e8..0871382ac475 100644
--- a/science/afni/pkg-plist
+++ b/science/afni/pkg-plist
@@ -1892,11 +1892,6 @@ lib/afni/plug_zeropad.so
 %%DATADIR%%/shiny/3dMVM_validator_shiny/stat_functions.R
 %%DATADIR%%/shiny/3dMVM_validator_shiny/ui.R
 %%DATADIR%%/shiny/ClustExp_ShinyTemplate/afni_funk.R
-%%DATADIR%%/shiny/ClustExp_ShinyTemplate/data/disco_ttest_GroupTable.csv
-%%DATADIR%%/shiny/ClustExp_ShinyTemplate/data/disco_ttest_StatInfo.csv
-%%DATADIR%%/shiny/ClustExp_ShinyTemplate/data/disco_ttest_p_uncor_0.005_clusters.csv
-%%DATADIR%%/shiny/ClustExp_ShinyTemplate/data/disco_ttest_p_uncor_0.005_mean.csv
-%%DATADIR%%/shiny/ClustExp_ShinyTemplate/data/disco_ttest_p_uncor_0.005_peak.csv
 %%DATADIR%%/shiny/ClustExp_ShinyTemplate/global.R
 %%DATADIR%%/shiny/ClustExp_ShinyTemplate/lib_Rafni.R
 %%DATADIR%%/shiny/ClustExp_ShinyTemplate/server.R